If your Neopet is feeling unwell, look in the list below to see what item you need to cure it. You can purchase the cures from the Neopian Pharmacy, or if they are sold out try asking the friendly Shop Wizard.
| Disease | Symptoms | Cure | |
| Neogitus | Your NeoPet’s gums become sore and swollen. It has difficulty eating or drinking. | Brush their teeth with a Medicinal Toothbrush |  |
| Bloaty Belly | This is what happens when your NeoPet eats too much. Your NeoPet will complain of being bloated and will refuse to eat anything. | Feed them some Flat-u-less Tablets |  |
| Fuzzitus | This is an allergy to fluff that all NeoPets get now and again, especially bad for JubJubs!! | Shake some Fluff Be Gone on their fur |  |
| Achy Head | Your NeoPet will have a nasty headache and feel very under the weather. | Rub some Magic Goop on their head |  |
| Shock -A- Lots | Your NeoPet’s fur will be full of static and anything it touches will give off electric sparks. | Wearing Ultra Rubber Gloves |  |
| Watery Eyes | Your NeoPet will look like it is constantly crying even though it may well be quite happy. | Rub Onion Balm around their eyes |  |
| NeoBlues | Your NeoPet is feeling very down in the dumps, it shows little or no interest in playing or eating anything. | A Tasty Pie will cheer them!!! |  |
| Floppy Tongue | Your NeoPet’s tongue has become all swollen and floppy. Your NeoPet will not be able to close its mouth and will drool a lot. | Give them a Tongue Shrinker Injection |  |
| Cricky Neck | Ouch – your NeoPet’s neck is very stiff and it can’t move its head at all. | Wear a special Neck Brace |  |
| NeoMites | Your beloved NeoPet’s coat is covered with lurgees that hop around and make your NeoPet scratch. | Give them a NeoMites Injection |  |
| Blurred Vision | Your NeoPet will see spots and may bump into things all the time. | Wearing Extra Thick Goggles |  |
| Neggitus | One too many Neggs can cause an allergic reaction, swelling of the ears and dizziness. | Give them a Neggitus Injection |  |
| Sneezles | Your NeoPet will have a runny nose and sneeze constantly. | Give them a Magic Cookie |  |
| D’achoo | Your NeoPet will go into a massive sneezing fit, and its eyes will become very sore. | Wipe their nose with Neopkins |  |
| Shaky Flakys | Your NeoPet will start trembling uncontrollably and its skin will be dry. In extreme cases, the skin may even start to flake off. | Rub some Shaky Flaky Cream on their skin |  |
| Grumbles | Your NeoPet’s stomach will begin to make the loudest of noises and it may be from its food | Take four Grumble Be Gone Tablets |  |
| Chickaroo | Your NeoPet will think it is a chicken, pecking the ground for food and crowing at dawn. | Feed them Herbal Scrambled Eggs |  |
| Bloaty Feet | Your NeoPet’s feet will swell and grow in size until you give it the necessary antidote. | Make them wear some Magic Smelly Socks |  |
| Kikoughela | Your NeoPet will have a sore throat and coughing fits. | Give them 2 spoonfuls of Kikoughela Syrup |  |
| Lumps | Your NeoPet will be covered in large, yellow, itchy lumps. | Give them a Medicinal Mud Bath |  |
| NeoPhobia | A chronic fear of leaving the house. | Make them wear a pair of Step Out Shoes |  |
| Hoochie Coochies | Your poor NeoPet will break out in blue and green spots. | Give them some Hoochie Coochie Tablets |  |
| NeoMonia | This is a nasty illness that needs urgent medical attention. Your NeoPet will feel sick, tired, and grumpy until you give it the cure. | Bathe them using Medicinal Soap |  |
| Neezles | Your NeoPet will break out in red spots if it’s suffering from Neezles. | Give them a Neezles Jab |  |
| Itchy Scratchies | A nasty disease where your NeoPet is covered in amazingly itchy red lumps. | Rub some Itchy Scratchy Cream on the lumps |  |
| NeoPox | If your NeoPet has NeoPox it will be covered in very itchy, contagious red blotches. | Feed them a slice of NeoPox Pizza |  |
| NeoWarts | Your NeoPet will have big cauliflower like lumps growing on its body. | Feed them some Neowart Fungus |  |
| Bubbles | Your poor NeoPet will constantly hiccup bubbles. | Give them a mug of Bubbles Herbal Drink |  |
| Neo Flu | Your NeoPet will refuse to eat, appear flushed and be very sleepy. | Feed them a handful of delicious Neoflu Jelly Pills. |  |
| Fuzzy Fungus | In the most severe cases your NeoPets fur can turn purple as it begins to turn into a Fungus Ball. | Give them one serving of Honey Blossom Extract |  |
| Ugga-Ugga | Possibly the worst Tyrannian disease, your Neopet’s throat becomes so sore that all they can do is make Ugga noises. | Give them a warm cup of Sporkle Syrup. |  |
| Reptillioritus | Caused by a bite from a venemous Reptillior, the skin becomes very red and itchy. Your Neopet will refuse to eat and feel very tired all the time. | Rub Cactopus Cream on the affected area. |  |
| Doldrums | Your NeoPet will start hiding in cold, dark, damp corners and won’t come out into the light. | Rub Mushroom Ointment on their face. |  |
| Jitters | If you notice that your NeoPet runs around constantly and just can’t seem to sit still to sleep, eat or do anything it might have this disease. | Feed your NeoPet Potion of Containment. |  |
| Spyder Bite | Caused by a bite from a wild Spyder, your NeoPet will appear very afraid of the Spider Grundo and Spyders. | Feed your NeoPet Spyder Juice Elixir. |  |
